Whoa. 1 is in the lead. o_O;
I personally am fond of 2 because there's color balance (hair & bow on head matches tail) and the splotches are BRIGHT in comparison to all the orangeness going on all over the rest of the body. It gives kind of a pop-out effect that brings some dynamic tension to her design. I'm not entirely sure about how I feel about the color of her hair, but that's up to what you want from her design.
I think the most important point in terms of designs is significance to you and to whatever the subject is. Random splashes, dots, splotches don't mean anything unless it's meaningful to you or to the subject. If you want to work on colors, try applying color theory? Opposite colors are my favorite color combos, but I also love to experiment with similar shades. As for markings, they can be random, but the randomness should be appealing to you and meaningful to the character (ask WHY do the markings look like this and not something else?). Just keep asking why why why and do I, personally, love these colors or am I just throwing things around? (These are just suggestions for experimentation that I usually do myself so, you can disregard this paragraph if you want)